Two-term Republican Marco Rubio was re-elected in 2016 with 52% of the vote. He announced on November 9, 2020, via Facebook, that he is running for re-election.
U.S. Representative Val Demings and former U.S. Representative Alan Grayson are running for the Democratic nomination.
Former U.S. Representative David Jolly, who was previously a Republican but is now independent, is considering running.
Ivanka Trump, daughter and former Senior Advisor to former President Donald Trump, was seen as a potential candidate to challenge Rubio for the Republican nomination. However, on February 18, 2021, it was confirmed that she would not seek the nomination.